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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHEK1 All Species: 37.58
Human Site: S357 Identified Species: 59.05
UniProt: O14757 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14757 NP_001107593.1 476 54420 S357 P D H M L L N S Q L L G T P G
Chimpanzee Pan troglodytes XP_001145968 476 54387 S357 P D H M L L N S Q L L G T P G
Rhesus Macaque Macaca mulatta XP_001111357 476 54432 S357 P D H M L L N S Q L L G T P G
Dog Lupus familis XP_852191 460 52810 S341 P D H M L L N S Q L L G T P G
Cat Felis silvestris
Mouse Mus musculus O35280 476 54363 S357 P E H M L V N S Q L L G T P G
Rat Rattus norvegicus Q91ZN7 476 54410 S357 P D H M L V N S Q L L G T P G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513209 476 53924 S357 P D H M L L N S Q L L A T P G
Chicken Gallus gallus Q8AYC9 476 53830 S357 P E H M L L N S Q L L G T P G
Frog Xenopus laevis Q6DE87 474 53957 S356 P D N M L L N S Q L I G T P G
Zebra Danio Brachydanio rerio NP_956487 410 46756 L308 S Q S P W Q R L V R R M T R F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O61661 512 57815 S369 L A Q E A R L S Y S F S Q P A
Honey Bee Apis mellifera XP_623436 467 53927 Q355 T S Q Q N T F Q R L V R R M T
Nematode Worm Caenorhab. elegans Q9N3Z3 503 56917 R377 R M V C R M T R F C V V T D I
Sea Urchin Strong. purpuratus NP_001091925 468 52554 A357 Q L Q C T P G A S Q T P M Q R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84VQ3 439 49610 S318 M N A F E L I S M S R A L D L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.3 93.2 N.A. 93.2 94.3 N.A. 89.9 84.4 77.7 56.9 N.A. 46 45.5 32 57.9
Protein Similarity: 100 100 99.7 95.1 N.A. 97 97.2 N.A. 95.3 91.5 86.7 71 N.A. 62.8 63.8 48.7 73.3
P-Site Identity: 100 100 100 100 N.A. 86.6 93.3 N.A. 93.3 93.3 86.6 6.6 N.A. 13.3 6.6 6.6 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 100 100 6.6 N.A. 13.3 20 20 6.6
Percent
Protein Identity: N.A. N.A. N.A. 32.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 52.1 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 0 7 0 0 7 0 0 0 14 0 0 7 % A
% Cys: 0 0 0 14 0 0 0 0 0 7 0 0 0 0 0 % C
% Asp: 0 47 0 0 0 0 0 0 0 0 0 0 0 14 0 % D
% Glu: 0 14 0 7 7 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 7 0 0 7 0 7 0 7 0 0 0 7 % F
% Gly: 0 0 0 0 0 0 7 0 0 0 0 54 0 0 60 % G
% His: 0 0 54 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 7 0 0 0 7 0 0 0 7 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 7 7 0 0 60 54 7 7 0 67 54 0 7 0 7 % L
% Met: 7 7 0 60 0 7 0 0 7 0 0 7 7 7 0 % M
% Asn: 0 7 7 0 7 0 60 0 0 0 0 0 0 0 0 % N
% Pro: 60 0 0 7 0 7 0 0 0 0 0 7 0 67 0 % P
% Gln: 7 7 20 7 0 7 0 7 60 7 0 0 7 7 0 % Q
% Arg: 7 0 0 0 7 7 7 7 7 7 14 7 7 7 7 % R
% Ser: 7 7 7 0 0 0 0 74 7 14 0 7 0 0 0 % S
% Thr: 7 0 0 0 7 7 7 0 0 0 7 0 74 0 7 % T
% Val: 0 0 7 0 0 14 0 0 7 0 14 7 0 0 0 % V
% Trp: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _